The New England Patriots and Atlanta Falcons were left searching for answers after surprise losses to the Tennessee Titans and Cleveland Browns respectively.
In Nashville, Marcus Mariota passed for 228 yards and two touchdowns and running back Derrick Henry rushed for 58 yards and two scores as the Titans thumped the Patriots 34-10.
The Titans' defense sacked Tom Brady three times and held the high-scoring Pats offense to 284 total yards. The Patriots fell to 7-3, while the Titans are 5-4.
In Cleveland, Browns rookie running back Nick Chubb rushed for 176 yards, added 33 more through the air and scored twice as the Browns upset Atlanta 28-16. He also provided the highlight of the day with a 92-yard TD run, the longest in franchise history.
Elsewhere, the two Los Angeles teams faced challenges but prevailed. In Oakland, Chargers quarterback Philip Rivers did not have a completion until the second quarter, but once he and running back Melvin Gordon got rolling, LA won 20-6 to improve to 7-2.
The Rams, who had never lost back-to-back games in the Sean McVay era, were close to doing so on Sunday when they hosted the Seahawks. Seattle quarterback Russell Wilson tried to engineer one of his famous fourth-quarter comebacks but fell short, going four-and-out on the final drive. Los Angeles (9-1) claimed a 36-31 victory to solidify their spot atop the NFC West.
Patriots receiver Julian Edelman injured his ankle in the team's loss to the Titans. He exited the game early and never returned. Other New England players that were injured in the contest were offensive tackle Trent Brown (back) and tight end Dwayne Allen (knee).
New Orleans left tackle Terron Armstead left the Saints' matchup against the Bengals after sustaining a shoulder injury during the first half. He was then ruled out of the game.
Raiders wide receiver Martavis Bryant was ruled out with a knee injury. A later report stated Bryant suffered a possible PCL tear, and will have an MRI to determine the severity of the injury.
A number of Packers were injured as Green Bay hosted the Dolphins. Safety Kentrell Brice left the game with an ankle injury, linebacker Nick Perry suffered a new injury, and guard Lucas Patrick was evaluated for a concussion.
Bengals cornerback Dre Kirkpatrick was unable to finish the game against the Saints after suffering a concussion.
Miami cornerback Bobby McCain was ruled out of the game with a head injury. Team-mate and receiver Jakeem Grant was carted off to the locker room with a leg injury. Fellow receiver DeVante Parker suffered a shoulder injury.
Rams wideout Cooper Kupp suffered another knee injury against the Seahawks and did not return.
By the numbers
Chiefs QB Patrick Mahomes threw for his 31st touchdown against the Cardinals, setting the franchise record for most touchdown passes in a single season, breaking a mark set by Len Dawson in 1964.
Single-season touchdown record broken...in 10 games. pic.twitter.com/V9HOhEcnoR— Kansas City Chiefs (@Chiefs) November 11, 2018
Falcons receiver Julio Jones became the fastest player in NFL history to reach 10,000 receiving yards. He reached the milestone in his 104th game.
Drew Brees passed Brett Favre for second-most passing touchdowns in NFL history, breaking the Hall of Famer's mark of 508 with three first-half touchdown passes against the Bengals.
The Redskins suffered a big loss to the Falcons last week. This time around, Washington were not going to be on the losing end. Linebacker Ryan Anderson attributed the win to a sense of urgency: "We got our [expletives] kicked last week, so everybody had a sense of urgency. That's what playing good defense is about. We let them make some plays, they hit us on some stuff. So, we had to just come out and respond. Bend, but don't break."
The Bills thrashed the Jets 41-10, leaving New York receiver Jermaine Kearse and company frustrated: "Everybody's frustrated. I understand the fans are frustrated. We're frustrated. It's understandable. We're going to stick together. We're going to stick with Todd [Bowles, head coach]. We're going to have his back."
Week 10 NFL scores
Pittsburgh Steelers 52, Carolina Panthers 21
Washington Redskins 16, Tampa Bay Buccaneers 3
Kansas City Chiefs 26, Arizona Cardinals 14
Cleveland Browns 28, Atlanta Falcons 16
Buffalo Bills 41, New York Jets 10
Indianapolis Colts 29, Jacksonville Jaguars 26
Chicago Bears 34, Detroit Lions 22
New Orleans Saints 51, Cincinnati Bengals 14
Tennessee Titans 34, New England Patriots 10
Los Angeles Chargers 20, Oakland Raiders 6
Los Angeles Rams 36, Seattle Seahawks 31
Green Bay Packers 31, Miami Dolphins 12
Dallas Cowboys 27, Philadelphia Eagles 20
|Cowboys top Eagles in OT behind stellar Cooper display|
|AC Milan evaluating Fabregas signing – Leonardo|
|WATCH: Steelers´ chance at game-tying field goal slips away|
|Hayne will plead not guilty to charges, says lawyer|
|Boca boss Schelotto: The only thing I feel is sadness|
|Cardinals´ Fitzgerald makes NFL history with most receptions for one team|
|River Plate´s Copa Libertadores star Gonzalo Martinez confirms January departure|
|Klopp: I was never worried about Salah´s form|
|Packers QB Rodgers sets NFL record for most passes without an interception|
|World Cup bulking hampered Man United form – Lukaku|
|Leonardo rules out Ibrahimovic Milan return|
|Warriors´ Green to return against Timberwolves|
|I feel for him… we´ll make it work – Butler responds to Embiid´s frustration|
|Torino draw no missed opportunity for misfiring AC Milan, claims Gattuso|
|We´ll always be linked together forever - Wade reflects on playing with James before final match-up|
|O´Sullivan wins record seventh UK title|
|Chiefs secure playoff berth, Saints win NFC South|
|River Plate 3 Boca Juniors 1 (aet, 5-3 agg): Quintero and Martinez clinch Libertadores title in extr|
|WATCH: Chiefs QB Mahomes throws no-look pass|
|Dolphins defeat Patriots on miraculous final play|
|Kizzire eagle snatches QBE Shootout victory|
|AC Milan 0 Torino 0: Donnarumma shines, Cutrone misses late chance|
|Back to the drawing board for West Indies - Chase|
|Copa Libertadores: Messi and Griezmann among stars in Madrid for River-Boca Superclasico|
|Brady sets NFL record for most career TD passes|
|Copa Libertadores: Tevez named on Boca bench for Superclasico final|
|Premier League needs VAR, right now! - Benitez fumes over Dean´s decisions|
|McCall expects Itoje to fit for the Six Nations|
|Solari salutes Real Madrid character after ´ugly´ Huesca win|
|Berbatov defends under-fire Lukaku|
|Sarries crush Blues to maintain unbeaten start|
|Newcastle United 1 Wolves 2: Doherty punishes Yedlin red with late winner|
|Deeney jokes he´ll ´smash´ former Watford star Richarlison|
|Huesca 0 Real Madrid 1: Bale ends drought as Solari´s men edge to victory|
|Ponting: Umpires not looking at no-balls|
|Bale ends longest LaLiga goal drought|
|Porter backs Brees for MVP, Saints for Super Bowl|
|Verstappen eyeing 2019 title fight|
|Wall ´shouldn´t have played´ against Cavaliers after scoring just one point|
|Hazard: Man City the best team in the Premier League despite Chelsea win|
|LeBron explains why he gave a Grizzlies employee his game-worn shoes|
|Bangladesh cruise to ODI victory as seamers punish Windies|
|Football will win over violence, claims CONMEBOL president|
|Alcorcon support Reus Deportiu over unpaid players|
|Saponara explains cheeky celebration after last-gasp leveller|
|Godin and Filipe Luis return to Atletico training|
|Kick It Out condemns alleged racist abuse of Sterling|
|Emotional Oosthuizen clinches South African Open title|
|The Sunday Seven - 7 Key Opta facts for NFL Week 14|
|Martino salutes Atlanta´s grand plan|
|India´s tail must show greater application - Bangar|
|Mourinho: Diogo Dalot can be new Gary Neville|
|Sterling hits out at media coverage of black players|
|Lyon roars with defiance as Australia aim for unlikely victory|
|Bulls coach Boylen: Hooked starters ´embarrassing´ in record loss|
|Martinez pays tribute to Martino, Almiron after MLS Cup glory|
|LeBron: Final Wade matchup will be bittersweet|
|Alvarez-Kovalev rematch set for February 2|
|Newcastle Jets 2 Brisbane Roar 0: Sheppard, Jair score first A-League goals|
|India close in on victory in first Test|
|LeBron flirts with triple-double as Lakers down Grizzlies|
|Lomachenko unifies WBO, WBA titles with win over Pedraza|
|Joshua wants Wilder and Fury fights – Hearn|
|Mavericks rookie Doncic leads impressive fourth-quarter surge to beat Rockets|
|Martinez named MLS Cup MVP|
|Oklahoma´s Murray wins the Heisman Trophy|
|Atlanta United 2 Portland Timbers 0: Martinez scores again as Martino´s men win MLS Cup|
|Sarri to use Hazard as centre forward again|
|Ballon d´Or is a lie – Alba says Messi is world´s best|
|Messi: I needed some luck with free-kicks|