Barcelona will secure top spot in their group with another positive result on Wednesday in what is arguably the biggest game of Champions League matchday five.
Lionel Messi is close to a personal milestone but Juventus will be desperate to avenge their 3-0 loss at Camp Nou and secure passage to the last 16 themselves.
Manchester United are also on the brink of the knockout phase and will look to fit-again Paul Pogba to improve on a pretty miserable record in the competition, while Paris Saint-Germain represent a daunting prospect for Celtic and Brendan Rodgers.
Chelsea will look to follow them into the next round and will hope Eden Hazard continues his electric form against Qarabag, while Atletico Madrid and Roma face off in a potentially pivotal showdown in the Spanish capital.
Below, we examine the key Opta numbers behind Wednesday's fixtures.
CSKA Moscow v Benfica
57 – CSKA are on six points after their first four matches; 57 per cent of sides to hold this record at this stage in the Champions League since 2003-04 (current format) have progressed to the next phase.
5 – Benfica have lost five Champions League matches in succession and have only managed to score once in this campaign; only Anderlecht have recorded fewer goals (0).
Basel v Manchester United
13 – No English side has ever managed to keep a clean sheet on the road against Basel in European competition (13 such fixtures); the Swiss club have claimed 1-0 victories in two of their last three home games versus English opposition.
33 – Paul Pogba has only scored two goals in 33 Champions League games.
Paris Saint-Germain v Celtic
17 – Paris Saint-Germain have scored more goals than anybody else this season in the Champions League (17) and are the only remaining side in the competition to record clean sheets in every game this term.
2 – Brendan Rodgers has won only two of his 16 group games as manager in the Champions League. Those victories came against Ludogorets (2-1) in September 2014, when he was in charge of Liverpool, and Celtic's 0-3 versus Anderlecht.
Anderlecht v Bayern Munich
18 – Anderlecht have only managed to register one clean sheet in their last 18 Champions League outings, while their German opponents have failed to record any in their last 10 on the road in this competition.
29 – Bayern Munich attempted 29 shots and hit the target 11 times in their 3-0 victory at home to Anderlecht on matchday one; Anderlecht recorded just one shot on target in response.
Qarabag v Chelsea
90 – Qarabag are yet to win a game this season in the Champions League; only on three previous occasions has a club progressed to the last 16 since 2003-04 (current format) in 90 instances after having failed to claim a win in the opening four matchdays.
17 – Eden Hazard has created more goalscoring chances than any other player in the 2017-18 Champions League campaign (17).
Atletico Madrid v Roma
4 – Roma have tasted defeat in four of their last five visits to Spanish clubs in the Champions League (W1), letting in 15 goals across those matches (an average of three per game).
9 – Nine of the last 14 Champions League goals scored by Atletico Madrid have seen the direct involvement of Antoine Griezmann (scored seven, assisted two).
Sporting CP v Olympiacos
1 – Only one team (Qarabag, seven) has recorded fewer shots on target this term in the Champions League than Olympiacos (nine); Sporting could only manage two on matchday four versus Juventus, but they came away with a 1-1 draw.
19 – Olympiacos' Silvio Proto has made 19 saves in three Champions League appearances this season, an average of over six per game, which is the highest rate of any keeper to register more than one outing in this campaign.
Juventus v Barcelona
29 – Juventus have only lost once in their last 29 home games against Spanish opposition in European competition (W19 D9), conceding only one goal across their last five such fixtures.
100 – Lionel Messi is just a hat-trick away from becoming only the second player to record 100 goals in the Champions League (after Cristiano Ronaldo). He scored a brace on matchday one against Juventus.
|New Zealand-born Aki will ´relish´ facing All Blacks – Marmion|
|Portugal cannot focus on absent Ronaldo - Santos|
|Ramsey reiterates he wants to stay with Jaguars despite cryptic tweet|
|We tried to hit a home run and it didn´t work out - D´Antoni explains Carmelo exit|
|West Ham´s Zabaleta backs Premier League´s VAR introduction|
|Southgate eyes winning end to England´s ´brilliant year´|
|Patient Zverev seizes opportunity to make amends at ATP Finals|
|Rodgers: Packers still believe they can make playoffs|
|Mahomes hoping to ketchup to Heinz´s touchdown target|
|Ranieri tells Fulham fans not to expect repeat of Leicester ´fairytale´|
|Brown to leave role as RFU chief executive|
|Croatia star Rakitic ruled out of England clash|
|Capital gains for Zverev as he secures last-four spot in London|
|Sancho rise continues with Player of the Month award|
|Jones-Buchanan, Ablett and Briscoe sign new Rhinos deals|
|Root leads from the front as aggressive England assume control|
|Croatia´s Lovren antagonises Ramos and ´rude´ Spain|
|Rakitic has ´enormous respect´ for England ahead of Nations League decider|
|Ireland make flanker switch with Leavy out of All Blacks clash|
|Pakistan rip through Black Caps in Abu Dhabi|
|WATCH: Barcelona mark 15-year anniversary of Messi´s first match|
|Sterling, that you? - Walker uses falling fan to poke fun at England team-mate|
|Fleetwood applies pressure on Molinari, Wallace leads in Dubai|
|Don´t talk to me about VAR – Rakitic not over World Cup final loss|
|Van Dijk leadership essential for Liverpool – Wijnaldum|
|Dalic: Croatia´s bench was ready to stop Spain!|
|Sublime Root century gives England imposing lead|
|Vinicius appreciates Solari influence at Real Madrid|
|Havertz would suit Bayern Munich – Kimmich|
|Wilder: Roach recruitment a sign of Fury nerves|
|Ranieri targets defensive improvements at failing Fulham|
|PSG close investigation into player recruitment practices after finding no discrimination|
|Mayweather: Nasukawa exhibition back on|
|Witsel: Joining Borussia Dortmund my best career decision|
|Ballon d´Or win would not change Modric´s ´best year´|
|Ireland v New Zealand: Opta stats behind the meeting of the world´s top two|
|The Breakdown: A statistical look at Saturday´s rugby internationals|
|Batshuayi dismisses reports of Valencia departure|
|Brazil must make Copa America final – Tite|
|Rockets rout Warriors as Green goes scoreless|
|Seahawks rally past Packers|
|Lakers G Rondo to miss 4-5 weeks|
|Durant is done with questions about Green|
|Smith, Warner set to return to IPL in 2019|
|No rivalry between Mbappe and Griezmann – Deschamps|
|Neymar: Emery will bring success to Arsenal|
|Jedvaj backs Croatia to deliver against England|
|Howell grabs first-round lead at Sea Island|
|Rooney backing Kane to break England record|
|Betts named American League MVP|
|Republic of Ireland must improve, says under-pressure O´Neill|
|Injured Sergio Ramos to leave Spain squad|
|Yelich named National League MVP|
|Low praises ´beautiful goals´ from Sane and Gnabry|
|Belgium boss Martinez pleased with patient Batshuayi|
|Wilson and Sancho pay tribute to England ´legend´ Rooney|
|Rooney gave England squad a lesson in humility - Southgate|
|This Week in U.S. Sports: LeBron passes Chamberlain, Williamson looking like he is next|
|We still have a chance - Luis Enrique not giving up hope after Spain defeat|
|Rockets ´parting ways´ with Anthony|
|Rooney became ´embarrassed´ at Manchester United|
|Federer: ´Easier´ to play when I´m up against it|
|Rooney convinced England are in safe hands with Southgate|
|Black Caps skipper Williamson confident over first Test availability|
|Federer cruises into last four of ATP Finals for 15th time|
|Republic of Ireland 0 Northern Ireland 0: Randolph saves light up bore draw|
|England 3 United States 0: Experimental side impresses on Rooney farewell|
|Croatia 3 Spain 2: Jedvaj keeps World Cup finalists in contention|
|Belgium 2 Iceland 0: Batshuayi rekindles Hazard flame with match-winning brace|
|Germany 3 Russia 0: Sane on target as Low´s men stroll|