Australia head to Twickenham with a spring in their step and eyeing revenge when they face England, while New Zealand take on Scotland and France host South Africa in another mouthwatering Saturday of international rugby.
England retained the Cook Cup by beating the Wallabies last year, but Michael Cheika's men are in fine form 12 months on and Eddie Jones' side must raise their game after a disjoined display in the win over Argentina.
World champions New Zealand head to Murrayfield on the back of being outplayed by France in the second half at Stade de France last weekend, having been outstanding in the opening 40 minutes to set up a victory in Paris.
Les Bleus will fancy their chances of seeing off a Springboks side that was hammered by Ireland, who should see off Fiji at the Aviva Stadium. Wales will aim to take the frustration of their latest loss to Australia out on Georgia.
With the help of Opta, we take a statistical look at the five Tests.
England v Australia
The Six Nations champions have won their last four matches against Jones' country of birth, including a 3-0 whitewash in Australia last year.
Australia have scored 55 tries in 2017, only twice have they scored more in a calendar year (64 in 2003, 56 in 1998).
England, who welcome Owen Farrell back into the side with Maro Itoje on the bench, are unbeaten in 12 games at Twickenham, their second-best sequence of victories at home. They won 22 in a row from October 1999 to September 2003.
France v South Africa
The Springboks whitewashed France 3-0 on home soil in June, all three victories by a margin of at least 22 points.
However, Les Bleus have come out on top in four of their last five home Tests against South Africa.
Antoine Dupont made four clean breaks, beat seven defenders and made 91 metres against New Zealand last Saturday. Since the 2015 Rugby World Cup, no tier one scrum-half has matched any of those statistics.
Ireland v Fiji
Joe Schmidt's side may not have expected to beat South Africa so emphatically, but they will be expected to rack up the points this weekend.
Ireland, who have handed a debut to centre Chris Farrell, have played only three Tests against Fiji, winning all three by 35 points or more.
Fiji wing Josua Tuisova has won 12 turnovers for Toulon in the TOP 14 this season, more than any other player in the competition this season, he's also crossed for five tries in his seven appearances.
Scotland v New Zealand
The All Blacks have never been beaten by Scotland in 30 Tests, only twice being held to a draw.
None of the current Scotland squad were born the last time they avoided defeat against the All Blacks – a 25-25 draw in 1983 – while Wyatt Crockett and Jerome Kaino are the only players in the world champions' touring squad to be born before that clash.
Scotland have won their last five matches at Murrayfield, their best winning sequence at the famous venue since a 13-game run from 1989 to 1991.
Wales v Georgia
This will be the first Test meeting between the two nations and Georgia will be looking for a first win against tier one opposition.
Wales missed just three of 153 attempted tackles [98 per cent success rate] against the Wallabies, the last time they missed fewer was in 2013 against Scotland. However, the 20 turnovers conceded was their highest figure in 15 matches.
Georgia full-back Soso Matiashvili scored 34 points against Canada last weekend, the most ever by a Lelos player in a Test match.
|I felt like I had been hit by a train - Halep upbeat despite losing Serena battle|
|Arsenal confirm Mislintat departure|
|Icardi will renew, 100 per cent - Wanda Nara offers latest Inter assurance|
|Japan 1 Saudi Arabia 0: Four-time winners send Pizzi´s men out|
|A souvlaki maybe named after him, a growing fan base – Tsitsipas creating Melbourne buzz|
|Barca winger Dembele out for 15 days|
|Strikers blown away by Hurricanes in Adelaide|
|Ireland lose Beirne for England and Scotland clashes|
|´Innate fighter´ Serena says character key to beating Halep|
|Hudson-Odoi ´an outstanding talent´ - Bayern great Ballack hails Chelsea youngster|
|Scotland call up four as hand injury forces Watson out|
|Serena comes through major Halep battle to reach last eight|
|Better than Rafa? Camacho cameo leaves Klopp unconvinced by transfer options|
|England job ´a privileged position´, says Southgate|
|Emery has confidence in Arsenal outcast Ozil|
|Zverev destroys racquet in Aus Open meltdown|
|From Villarreal to Aus Open quarters – Bautista Agut breaks major duck|
|Brees: I plan on being here next year and making another run at it|
|´Unf******-believable bro!´ - Brady stunned after reaching third straight Super Bowl|
|New England find answers, penalty costs Kansas City – three takeaways from Patriots´ win over Chiefs|
|Donald Trump congratulates Brady and Super Bowl-bound Patriots|
|Rose helps Timberwolves down Suns|
|Brady leads Patriots into third straight Super Bowl|
|Osaka overcomes Sevastova to reach quarters|
|Chelsea remain behind Sarri – David Luiz|
|McVay explains Gurley´s limited role in Rams´ win over Saints|
|Southgate hails ´tremendous talent´ Rashford|
|Long earns maiden PGA Tour win at Desert Classic|
|Flanagan resigns as Sharks head coach|
|Rams´ Robey-Coleman admits he committed penalty on controversial no-call|
|NFL admits they blew the call – Saints coach Payton|
|Terrible no-call, Goff shines – three takeaways from Rams´ win over Saints|
|Lonzo Ball to miss 4-6 weeks with ankle sprain|
|Patterson added to Australia Test squad|
|Zuerlein´s overtime kick sinks Saints and sends Rams to Super Bowl|
|It was a clear goal – Valverde dismisses Barca VAR controversy|
|Rashford can emulate Man United greats Ronaldo and Rooney – Solskjaer|
|Karmichael Hunt swaps Reds for Waratahs|
|Barcelona forward Dembele set for tests on sprained ankle|
|Neymar insists Barcelona and Real Madrid links not ´concrete´|
|England trio Nowell, Slade and Cowan-Dickie sign fresh Exeter deals|
|Windies coach Pybus not distracted by detractors|
|Barcelona 3 Leganes 1: Messi and Suarez combine to spare Barca´s blushes|
|I´m sure Michael would be extremely proud - Vettel hails Mick Schumacher|
|Young plays down injury fears for England trio Launchbury, Shields and Hughes|
|Pochettino: Lucas Moura fit for Chelsea clash|
|Ranieri positive on Fulham survival chances despite ´unbelievable´ Spurs loss|
|United Arab Emirates v Kyrgyzstan: Zaccheroni confident in attack|
|South Korea lose Ki to hamstring injury|
|It doesn´t look great - Pochettino to wait on Alli assessment|
|Messi benched as Barcelona face Leganes|
|Dalglish texts me before matches - Van Dijk|
|Patrick Mahomes could sign NFL´s first $200m contract - reports|
|Iran 2 Oman 0: Jahanbakhsh and Dejagah secure last-eight spot|
|Helloooo u remember me? Nkoudou reminds Spurs fans he exists|
|Japan v Saudi Arabia: Pizzi believes Saudis can upset the odds|
|Repsol Honda´s Lorenzo to have surgery on fractured wrist|
|Fulham 1 Tottenham 2: Winks heads late winner after Alli injury|
|Leinster seal home quarter-final with win over Wasps|
|Vince, Curran star as Sixers trounce Heat to move second|
|Sharapova stunned by Barty as Kvitova takes Anisimova to school|
|Guardiola demands improvement after Man City win|
|Sexton has bat phone to referees - Jones|
|Alonso accepts Chelsea guilty of ´silly mistakes´ in Arsenal defeat|
|Guardiola woke us up - Sane reveals half-time rocket for Man City|
|A first step to something bigger - Tsitsipas eyeing glory after shocking Federer|
|Thailand 1 China 2: Gao Lin keeps dream alive for Lippi|
|Tsitsipas in dreamland after ousting Federer, birthday boy Tiafoe breaks new ground|
|Huddersfield Town 0 Manchester City 3: Danilo, Sterling and Sane on target for ton-up City|
|Allegri: Khedira will be like a new signing for Juventus|