Cruzeiro coach Mano Menezes complained of a conspiracy against Brazilian clubs after Dede was shown a red card for a challenge that left Boca Juniors goalkeeper Esteban Andrada with a fractured jaw.
Dede was dismissed with the use of VAR after his attempt at a header saw him miss the ball and catch Andrada in the 75th minute of the Copa Libertadores quarter-final first-leg clash at La Bombonera on Wednesday.
Menezes' men were trailing to Mauro Zarate's first-half strike when the Brazil centre-back was given his marching orders, and Pablo Perez's effort eight minutes from time clinched a 2-0 win for the Superliga side.
The Cruzeiro boss was unimpressed with the decision to send off Dede and asked the Brazilian Football Confederation (CBF) to provide greater protection to their teams.
"We have VAR so we do not have great injustices in football, and we saw a great injustice. We lost a player in our best moment of the game," said Menezes, who highlighted how CONMEBOL has dealt with ineligible players in the Libertadores this season.
The governing body awarded Independiente a 3-0 win over Santos after the Brazilian side fielded Carlos Sanchez in their last-16 first leg despite a suspension, while Boca and River Plate avoided punishment for selecting Ramon Abila and Bruno Zuculini respectively despite bans.
"Someone who wasn't on the field thought something was different. No Boca player did – so much so that they thought it was something against them," added Menezes.
"The referee made the decision and he is to blame for everything that happened.
"The referee wanted to dismiss Dede, and the problem is there are a lot of things against Brazilian teams. There was the case of Santos, the lack of punishment applied to River and Boca. Things are very different.
"It's something that doesn't smell good. I think the CBF and other federations have to take a stand. This is something serious. It has to be treated by Brazilian clubs seriously."
Andrada is expected to miss the Superclasico between Boca and River at La Bombonera on Sunday and Guillermo Barros Schelotto backed the process behind Dede's dismissal.
"They must have had some reason for the red card," said the Boca head coach.
"There is the referee on the pitch and another three watching the VAR, and I think the situation is very clear, they will have had a reason to throw Dede out.
"When we play with VAR we have to respect the law more than ever because not only is there the referee on the pitch, but there are also three others out watching everything that happens."
|Mourinho compares Liverpool to ´an amazing house´ but insists trophies matter|
|Brisbane Roar 2 Melbourne Victory 4: Muscat´s men hit A-League summit|
|Bumrah confident second Test is ´in the balance´ after India recovery|
|Isco gesture was for a corner or foul, claims Solari|
|Harris leads Australia into ascendancy on day one|
|ATP announces candidates to host future Finals|
|Ronaldo: Juventus fans refuse to lose to Torino|
|Hero Rivers feared he had cost Chargers in KC|
|Williams would welcome Llorente back to Athletic Bilbao|
|Liverpool v Manchester United: Minding the gap|
|Milan elimination unjust, fumes Leonardo|
|Paul hails ´sick´ Harden after record-breaking display|
|Liverpool v Manchester United: Salah, Mane and Firmino v Rashford, Martial and Lukaku in Opta number|
|Canelo open to GGG trilogy as he chases place in Mexican history|
|The big Friday Premier League quiz|
|Harden posts record fourth 50-point triple-double in win over Lakers|
|Barcelona squad happy with Dembele, says Alba|
|Chargers rally past Chiefs to clinch playoff spot|
|WATCH: Chargers top Chiefs on dramatic two-point conversion in final seconds|
|Suns owner Sarver committed to keeping team in Phoenix|
|Chargers WR Allen leaves with injury after near-spectacular catch|
|Socceroos not giving up on Mooy for Asian Cup|
|Cooper says Raiders owner wanted to trade him to Cowboys|
|Pochettino jokes Levy is ´worried´ about losing him|
|Barcelona would welcome Morata – Alba|
|Toure not a priority for West Ham – Pellegrini|
|Koscielny no certainty to face Southampton, says Emery|
|We gifted the game – AC Milan boss Gattuso furious after Europa League exit|
|My season starts now, says Koscielny|
|Cipriani ´at peace´ with latest England snub|
|Laporte: Deschamps must have personal reasons for France snub|
|Morata injury not too serious, claims Chelsea boss Sarri|
|Hansen to leave: All Blacks coach returning focus to World Cup defence|
|I want to fight the champion! - Joshua reiterates Wilder in April ambition|
|Gundogan glad to leave Christmas holidays behind|
|I know how it feels and it hurts - Gundogan on Sterling abuse|
|Celtic 1 Red Bull Salzburg 2: Scottish champions through despite defeat|
|Olympiacos 3 AC Milan 1: Rossoneri crash out of Europa League|
|Arsenal 1 Qarabag 0: Lacazette on target as Saka shines|
|Hansen to leave: All Blacks will take time to name replacement|
|Chelsea condemn alleged anti-Semitic chanting from fans|
|Hansen to leave: The best Opta facts from New Zealand coach´s tenure|
|Hansen to leave: Five contenders to be the next All Blacks coach|
|Hansen to leave: Highs and highs of his All Blacks reign|
|Hansen to leave All Blacks after World Cup|
|Rapid Vienna 1 Rangers 0: Late Ljubicic winner sends Gerrard´s men out|
|Beckham continues to miss Giants practice with quad injury|
|Vidi 2 Chelsea 2: Giroud spares Sarri´s side in lacklustre draw|
|Paris Saint-Germain and Marseille fixtures among latest Ligue 1 cancellations|
|Santos turn to ex-Argentina boss Sampaoli|
|Muller could miss Champions League last 16 after Tagliafico kick|
|Home hope Bekker out in front at Alfred Dunhill Championship|
|Van Bommel in touch with Robben over PSV reunion|
|Pinarello chief confident over Team Sky future|
|Stade make Ospreys tickets free in tribute to teenager|
|WRC great Loeb seals Hyundai switch|
|Madrid rumours better than sack talk, says Pochettino|
|Nadal to join Federer at 2019 Laver Cup|
|Prigoda smashes world record, Hosszu dethroned in Hangzhou|
|Former Juve CEO Marotta takes over at Inter|
|Glenn to stand down as FA boss next year|
|Muller apologises to Tagliafico for kick to the head|
|Pereira pleads for more Manchester United chances|
|Griffin hails ´phenomenal´ Lowry after Warriors demolition|
|I´ve played with Zidane and Henry, but Messi is something else – Pires|
|Dragons forward Jack de Belin charged with sexual assault|
|Durant: Raptors are the real deal|
|Cocu bids farewell to Fenerbahce after ´mutual agreement´ is made over October sacking|
|Australia unchanged for historic Perth Test|
|Champions League draw: The possible last-16 ties|