Danny Willett won a tournament for the first time since becoming Masters champion in 2016 at the DP World Tour Championship, while Francesco Molinari wrapped up the Race to Dubai title.
Willett suffered a loss of form following his unexpected triumph at Augusta but held off the challenge of fellow Englishman Matt Wallace and reigning Masters champion Patrick Reed, with whom he shared the overnight lead, to come away with the victory.
The 31-year-old finished two shots clear of Wallace and Reed on 18 under par, despite bogeys at holes 10 and 12.
Molinari finished in a tie for 26th, but Tommy Fleetwood's failure to win the event - ending the weekend in 16th - was enough to see the Italian end the season as Europe's number one golfer.
Wallace joined Willett at the summit following the eventual winner's quickfire bogeys, but three birdies across the last five holes were enough to re-establish the cushion.
Reed struggled to keep pace with Willett on Sunday and was two over through the front nine.
He managed five birdies and a bogey after the turn but his efforts were not enough to elevate him back to the top of the leaderboard.
Jon Rahm, Adrian Otaegui and Dean Burmester were a further two shots adrift of Wallace and Reed in a tie for fourth.
Molinari's triumph brings to a close a season in which he won The Open and the BMW PGA Championship.
The 36-year-old was also one of the stars of Europe's victory in the Ryder Cup, forming a formidable pairing with Fleetwood that became known as 'Moliwood'.
Molinari, finishing the tournament six under par, becomes the first Italian to top the European Tour's money list.
"It's incredible," said Molinari. "Now I'm going to have time to sit down and relax and really think back about the last few months.
"This morning on the first tee the announcement is the winner of The Open Championship, Race to Dubai leader, it doesn't sound real at the moment.
"It's more than I ever dreamed of achieving. I've seen guys that I think are better players than me not winning majors and not winning Order of Merits or Race to Dubais. To achieve those things in one single season is just incredible."
|Hayne will plead not guilty to charges, says lawyer|
|Boca boss Schelotto: The only thing I feel is sadness|
|Cardinals´ Fitzgerald makes NFL history with most receptions for one team|
|River Plate´s Copa Libertadores star Gonzalo Martinez confirms January departure|
|Klopp: I was never worried about Salah´s form|
|Packers QB Rodgers sets NFL record for most passes without an interception|
|World Cup bulking hampered Man United form – Lukaku|
|Leonardo rules out Ibrahimovic Milan return|
|Warriors´ Green to return against Timberwolves|
|I feel for him… we´ll make it work – Butler responds to Embiid´s frustration|
|Torino draw no missed opportunity for misfiring AC Milan, claims Gattuso|
|We´ll always be linked together forever - Wade reflects on playing with James before final match-up|
|O´Sullivan wins record seventh UK title|
|Chiefs secure playoff berth, Saints win NFC South|
|River Plate 3 Boca Juniors 1 (aet, 5-3 agg): Quintero and Martinez clinch Libertadores title in extr|
|WATCH: Chiefs QB Mahomes throws no-look pass|
|Dolphins defeat Patriots on miraculous final play|
|Kizzire eagle snatches QBE Shootout victory|
|AC Milan 0 Torino 0: Donnarumma shines, Cutrone misses late chance|
|Back to the drawing board for West Indies - Chase|
|Copa Libertadores: Messi and Griezmann among stars in Madrid for River-Boca Superclasico|
|Brady sets NFL record for most career TD passes|
|Copa Libertadores: Tevez named on Boca bench for Superclasico final|
|Premier League needs VAR, right now! - Benitez fumes over Dean´s decisions|
|McCall expects Itoje to fit for the Six Nations|
|Solari salutes Real Madrid character after ´ugly´ Huesca win|
|Berbatov defends under-fire Lukaku|
|Sarries crush Blues to maintain unbeaten start|
|Newcastle United 1 Wolves 2: Doherty punishes Yedlin red with late winner|
|Deeney jokes he´ll ´smash´ former Watford star Richarlison|
|Huesca 0 Real Madrid 1: Bale ends drought as Solari´s men edge to victory|
|Ponting: Umpires not looking at no-balls|
|Bale ends longest LaLiga goal drought|
|Porter backs Brees for MVP, Saints for Super Bowl|
|Verstappen eyeing 2019 title fight|
|Wall ´shouldn´t have played´ against Cavaliers after scoring just one point|
|Hazard: Man City the best team in the Premier League despite Chelsea win|
|LeBron explains why he gave a Grizzlies employee his game-worn shoes|
|Bangladesh cruise to ODI victory as seamers punish Windies|
|Football will win over violence, claims CONMEBOL president|
|Alcorcon support Reus Deportiu over unpaid players|
|Saponara explains cheeky celebration after last-gasp leveller|
|Godin and Filipe Luis return to Atletico training|
|Kick It Out condemns alleged racist abuse of Sterling|
|Emotional Oosthuizen clinches South African Open title|
|The Sunday Seven - 7 Key Opta facts for NFL Week 14|
|Martino salutes Atlanta´s grand plan|
|India´s tail must show greater application - Bangar|
|Mourinho: Diogo Dalot can be new Gary Neville|
|Sterling hits out at media coverage of black players|
|Lyon roars with defiance as Australia aim for unlikely victory|
|Bulls coach Boylen: Hooked starters ´embarrassing´ in record loss|
|Martinez pays tribute to Martino, Almiron after MLS Cup glory|
|LeBron: Final Wade matchup will be bittersweet|
|Alvarez-Kovalev rematch set for February 2|
|Newcastle Jets 2 Brisbane Roar 0: Sheppard, Jair score first A-League goals|
|India close in on victory in first Test|
|LeBron flirts with triple-double as Lakers down Grizzlies|
|Lomachenko unifies WBO, WBA titles with win over Pedraza|
|Joshua wants Wilder and Fury fights – Hearn|
|Mavericks rookie Doncic leads impressive fourth-quarter surge to beat Rockets|
|Martinez named MLS Cup MVP|
|Oklahoma´s Murray wins the Heisman Trophy|
|Atlanta United 2 Portland Timbers 0: Martinez scores again as Martino´s men win MLS Cup|
|Sarri to use Hazard as centre forward again|
|Ballon d´Or is a lie – Alba says Messi is world´s best|
|Messi: I needed some luck with free-kicks|
|Hoffman, Woodland in three-way tie for lead|
|Brook unconvincing in Zerafa victory|
|Leo unties any game - Valverde hails mesmeric Messi|